Comparative Study of Biochemical Markers in Prostatitis, Benign Prostate Hypertrophy and Carcinoma of Prostate with and without Metastasis

BACKGROUND: Prostate cancer is a very slow progressing disease of the male reproductive system. High levels of Prostate specific antigen in the serum are might be an indication of either prostate cancer or some conditions like Benign prostate hypertrophy.The Diagnosis is confirmed by histological examinations of biopsy, trans urethral prostate resection or by aspiration cytology.METHODS: A total of 125 male subjects were devided in five groups ( I: 25 healthy men selected as control II : 25 individuals with prostatitis. III: 25 men with Benign prostate hypertrophy. IV: 25 men with carcinoma prostate without metastasis.V: 25 men with Carcinoma prostate with metastasis.) and different Biochemical parameters like Prostate specific antigen , Total acid phosphatase , Prostate fraction of acid phosphatase, Blood Urea , Serum Creatinine and Serum Uriacid were estimated on the blood samples. Statistical analysis done by Calculating the sensitivity, specificity and diagnostic efficacy by using the best cut off values and ROC curves for different analytes. RESULTS: The present study shows significantly high Prostate specific antigen values in patients of carcinoma prostate with and without metastasis compared to controls and prostatitis. The sensitivity and specificity of Prostate specific antigen was higher than those of Total acid phosphatase and Prostate fraction of acidphosphatase.CONCLUSION: Among the Biochemical markers , the diagnostic accuracy is better with Prostate specific antigen followed by the prostatic fraction of acid Phosphatase for the diagnosis of Hypertrophy and carcinoma of Prostate gland.